Virelizier J L
Presse Med. 1984 Feb 25;13(8):495-8.
Defective production of either alpha, beta or gamma interferon has been observed in association with severe infections, hematological disorders or immunosuppression. The secretion of gamma interferon can be used as a marker of T lymphocyte function in cases of qualitative T cell defects. In rare patients, a selective defect of interferon production is associated with severe of persistent infections and in some cases with polyclonal immunoblastic proliferation in the absence of other detectable immuno-deficiency. The secondary defect of natural killer cytotoxicity observed in such patients can be reversed by interferon therapy. This new approach to clinical investigation and therapy is likely to widen with the study of other immunoregulatory mediators.
在严重感染、血液系统疾病或免疫抑制的情况下，已观察到α、β或γ干扰素产生存在缺陷。在T细胞定性缺陷的病例中，γ干扰素的分泌可作为T淋巴细胞功能的标志物。在罕见患者中，干扰素产生的选择性缺陷与严重或持续性感染相关，在某些情况下与无其他可检测免疫缺陷时的多克隆免疫母细胞增殖相关。在此类患者中观察到的自然杀伤细胞细胞毒性的继发性缺陷可通过干扰素治疗逆转。随着对其他免疫调节介质的研究，这种临床研究和治疗的新方法可能会得到拓展。
