Sabina R L, Holmes E W, Becker M A
Science. 1984 Mar 16;223(4641):1193-5. doi: 10.1126/science.6199843.
5-Amino-4-imidazolecarboxamide riboside triphosphate (ZTP) is thought to play a regulatory role in cellular metabolism. Unlike other nucleoside triphosphates, ZTP is synthesized in a one-step reaction in which the pyrophosphate group of 5-phosphoribosyl-l-pyrophosphate is transferred to the riboside monophosphate (ZMP) in a reaction catalyzed by 5-phosphoribosyl-l-pyrophosphate synthetase; reversal of this reaction leads to dephosphorylation of ZTP to ZMP. This unusual route of synthesis (and catabolism) of ZTP may be important in defining its metabolic effects in the cell.
5-氨基-4-咪唑甲酰胺核糖三磷酸（ZTP）被认为在细胞代谢中发挥调节作用。与其他核苷三磷酸不同，ZTP通过一步反应合成，其中5-磷酸核糖-1-焦磷酸的焦磷酸基团在5-磷酸核糖-1-焦磷酸合成酶催化的反应中转移至核糖单磷酸（ZMP）；该反应的逆反应导致ZTP去磷酸化生成ZMP。ZTP这种不寻常的合成（及分解代谢）途径可能对确定其在细胞中的代谢作用很重要。
