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[病毒诱导的劳舍尔白血病小鼠脾细胞中的多聚腺苷酸化RNA和多聚A片段]

[Polyadenylated RNA and poly-A segments in the splenic cells of mice with virus-induced Rauscher leukemia].

作者信息

Smirnova I A, Nakonechnyĭ N V

出版信息

Vopr Med Khim. 1983 Nov-Dec;29(6):63-9.

PMID:6199896
Abstract

In spleen cells of mice with Rauscher++ leukosis polyadenilation of RNA was impaired: an increase in content of Gya poly(A)+ RNA and a change in the composition of poly-A-segments were observed. In DNA of leukemic and normal cells dA-fragments were found content of which was increased in leukemic cells as compared with normal ones. Leukemic transformation appears to be accompanied by appearance of the additional poly-A-fragments in the cells.

摘要

在患有劳斯氏++白血病的小鼠脾细胞中,RNA的多聚腺苷酸化受到损害:观察到Gya多聚(A)+RNA含量增加以及多聚A片段组成发生变化。在白血病细胞和正常细胞的DNA中发现了dA片段,与正常细胞相比,白血病细胞中其含量增加。白血病转化似乎伴随着细胞中额外多聚A片段的出现。

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