Cassel G H, Groden L R
Ann Ophthalmol. 1984 Feb;16(2):138-41.
Although the final common pathway of ocular neovascularization has been produced by a variety of stimuli in various locations in the eye, a specific unifying mechanism has not been generally accepted. Regeneration in lower vertebrates is a phenomenon that closely parallels new vessel growth in the eye, especially in its ontogenic potential and may give clues to its pathogenesis. The importance of a neural factor in regeneration has been demonstrated using several models. Interestingly, ocular tissues such as the iris, lens, and neural retina exhibits some of the most remarkable evidence for this regenerative mechanism. This article explores, through various developmental associations and clinical observations, the concept of ocular neovascularization as a neurally mediated regenerative process. Recent research utilizing a model of corneal denervation has added further support to this association.
尽管眼部新生血管形成的最终共同途径是由眼睛不同部位的多种刺激产生的，但尚未普遍接受一种特定的统一机制。低等脊椎动物的再生是一种与眼睛新血管生长密切平行的现象，尤其是在其个体发育潜能方面，可能为其发病机制提供线索。使用几种模型已经证明了神经因子在再生中的重要性。有趣的是，虹膜、晶状体和神经视网膜等眼部组织为这种再生机制提供了一些最显著的证据。本文通过各种发育关联和临床观察，探讨了眼部新生血管形成作为一种神经介导的再生过程的概念。最近利用角膜去神经模型的研究进一步支持了这种关联。
