Jorge E, Harvey H A, Simmonds M A, Lipton A, Joehl R J
Ann Surg. 1984 Mar;199(3):328-31. doi: 10.1097/00000658-198403000-00013.
Malignant melanoma involving the gastrointestinal tract is a common autopsy finding in patients who die with this disease. Melanoma metastatic to bowel infrequently causes symptoms. Some investigators suggest that survival following the onset of gastrointestinal symptoms is very poor and, as a result, surgical intervention to relieve symptoms should be avoided. We reviewed the clinical courses of 15 consecutive patients with symptomatic malignant melanoma of the bowel who underwent resection alone or in combination with bypass of symptomatic intestinal lesions. There were no deaths within 30 days of operation; 14 patients obtained relief of intestinal symptoms; 11 patients survived a mean of 7.9 months; and four patients are alive 2, 7, 22, and 23 months after operation. These results suggest that operations to treat symptomatic intestinal melanoma provide reasonable palliation and survival for patients with this disease.
胃肠道恶性黑色素瘤是死于该疾病患者尸检中的常见发现。转移至肠道的黑色素瘤很少引起症状。一些研究者认为，胃肠道症状出现后的生存率很低，因此应避免通过手术干预来缓解症状。我们回顾了15例连续性有症状的肠道恶性黑色素瘤患者的临床病程，这些患者单独接受了手术，或在切除有症状肠道病变的同时进行了旁路手术。术后30天内无死亡病例；14例患者的肠道症状得到缓解；11例患者平均存活7.9个月；4例患者术后2个月、7个月、22个月和23个月仍存活。这些结果表明，手术治疗有症状的肠道黑色素瘤可为该病患者提供合理的姑息治疗和生存机会。
