Gwilt D J, Nagle R E
Br Heart J. 1984 Apr;51(4):427-30. doi: 10.1136/hrt.51.4.427.
Forty consecutive patients with coronary artery disease undergoing left ventricular angiography took part in a randomised double blind trial comparing a conventional contrast medium sodium meglumine iothalamate (Cardio-Conray) with the low osmolar agent iopamidol. Iopamidol produced a smaller rise in heart rate and a smaller fall in left ventricular systolic pressure, but the changes in left ventricular and diastolic pressure and maximum rate of change of pressure (dP/dt max) were not different. The numbers of extrasystoles per minute for five minutes after ventriculography were similar in both groups except for the first 15 seconds, when the number of extrasystoles was increased in the iopamidol group. The frequency and magnitude of symptoms (heat, angina, headache, nausea) were significantly different in two groups. Iopamidol caused less haemodynamic disturbance than Cardio-Conray, although the improvement is small and offers no advantage in reducing symptoms or extrasystoles.
40例接受左心室造影的冠心病患者参与了一项随机双盲试验，该试验比较了传统造影剂碘他拉葡甲胺（Cardio-Conray）与低渗造影剂碘帕醇。碘帕醇使心率升高幅度较小，左心室收缩压下降幅度较小，但左心室和舒张压的变化以及压力最大变化率（dP/dt max）并无差异。两组心室造影后5分钟每分钟的早搏次数相似，但在最初15秒时除外，此时碘帕醇组的早搏次数增加。两组症状（潮热、心绞痛、头痛、恶心）的频率和严重程度有显著差异。碘帕醇引起的血流动力学紊乱比碘他拉葡甲胺少，尽管改善程度较小，且在减轻症状或减少早搏方面并无优势。
