化学性肝癌发生过程中肝脏酪氨酸转氨酶信使核糖核酸水平的变化。
Changes in hepatic levels of tyrosine aminotransferase messenger RNA during chemical hepatocarcinogenesis.
作者信息
Huang D P, Maine A B, Chiu J F
出版信息
Cancer Lett. 1984 Mar;22(2):143-9. doi: 10.1016/0304-3835(84)90111-3.
The activity of tyrosine aminotransferase (TAT) decreased biphasically in livers of rats fed 3'-methyl-4-dimethylaminoazobenzene (3'-MDAB). TAT activity decreased to an extremely low level at later stages of hepatocarcinogenesis. The activity of TAT is negatively correlated with alpha-fetoprotein (AFP) levels. The level of TAT enzyme activity in precancerous liver and hepatoma is a reflection of the amount of TAT mRNA. Dexamethasone increased the TAT enzyme activity and TAT mRNA concentration in rat livers during chemical carcinogenesis.
给喂食3'-甲基-4-二甲基氨基偶氮苯（3'-MDAB）的大鼠肝脏中，酪氨酸转氨酶（TAT）的活性呈双相下降。在肝癌发生的后期，TAT活性降至极低水平。TAT活性与甲胎蛋白（AFP）水平呈负相关。癌前肝脏和肝癌中TAT酶活性水平反映了TAT mRNA的量。在化学致癌过程中，地塞米松增加了大鼠肝脏中的TAT酶活性和TAT mRNA浓度。
Zotero 插件