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利多卡因作为抗心律失常药物的当前认识：综述

Current understanding of lidocaine as an antiarrhythmic agent: a review.

作者信息

Anderson J L

出版信息

Clin Ther. 1984;6(2):125-41.

PMID:6200230
Abstract

Lidocaine generally is the agent of first choice against acute ventricular arrhythmias arising from many causes. It is clinically effective and well tolerated, having a rapid onset of action and a favorable electrophysiological profile. Unlike other antiarrhythmic agents, lidocaine does not interact with the autonomic nervous system. A review of the literature highlights current knowledge about this antiarrhythmic drug.

摘要

利多卡因通常是治疗多种原因引起的急性室性心律失常的首选药物。它临床疗效显著且耐受性良好，起效迅速，电生理特性良好。与其他抗心律失常药物不同，利多卡因不与自主神经系统相互作用。一篇文献综述突出了关于这种抗心律失常药物的现有知识。

相似文献

1
Current understanding of lidocaine as an antiarrhythmic agent: a review.利多卡因作为抗心律失常药物的当前认识：综述
Clin Ther. 1984;6(2):125-41.
2
[Value of lidocaine in the prevention of ventricular arrhythmias in the acute phase of myocardial infarct].[利多卡因在预防心肌梗死急性期室性心律失常中的价值]
Arq Bras Cardiol. 1983 Jun;40(6):377-81.
3
Lidocaine (Xylocaine) as an anti-arrhythmic agent.利多卡因（赛罗卡因）作为一种抗心律失常药物。
Med Lett Drugs Ther. 1971 Jan 8;13(1):1-2.
4
The pharmacology and clinical use of lidocaine as an antiarrhythmic drug--1972.
Mod Treat. 1972 Feb;9(1):139-75.
5
[Tetrodotoxin potentiation of the antiarrhythmic action of lidocaine in the late stage of experimental myocardial infarct].[河豚毒素对实验性心肌梗死后期利多卡因抗心律失常作用的增强作用]
Biull Eksp Biol Med. 1981;91(1):38-40.
6
Intramuscularly and orally administered lidocaine in the treatment of ventricular arrhythmias in acute myocardial infarction.
Am J Cardiol. 1972 Apr;29(4):514-9. doi: 10.1016/0002-9149(72)90441-9.
7
Re-entrant ventricular arrhythmias in the late myocardial infarction period. 4. Mechanism of action of lidocaine.
Circulation. 1977 Sep;56(3):395-402. doi: 10.1161/01.cir.56.3.395.
8
[Lidocaine and arrhythmias].
Medicina (B Aires). 1972 Mar-Apr;32(2):168-82.
9
[Comparison of aprindine (AC 1802) and lidocaine by intravenous route during the acute phase of myocardial infarct].心肌梗死急性期静脉注射阿普林定（AC 1802）与利多卡因的比较
Acta Cardiol. 1974;Suppl 18:423-32.
10
Antiarrhythmic actions of tocainide in canine models of previous myocardial infarction.妥卡尼在前壁心肌梗死犬模型中的抗心律失常作用。
Am Heart J. 1991 May;121(5):1413-21. doi: 10.1016/0002-8703(91)90147-a.

引用本文的文献

1
Prophylactic lidocaine for myocardial infarction.用于心肌梗死的预防性利多卡因。
Cochrane Database Syst Rev. 2015 Aug 21;2015(8):CD008553. doi: 10.1002/14651858.CD008553.pub2.
2
5% Lidocaine Medicated Plaster for the Treatment of Postherpetic Neuralgia: A Review of the Clinical Safety and Tolerability.5% 利多卡因贴剂治疗带状疱疹后神经痛：临床安全性和耐受性评价。
Pain Ther. 2015 Jun;4(1):1-15. doi: 10.1007/s40122-015-0034-x. Epub 2015 Apr 21.
3
Lidocaine improves survival rate in diabetic rats submitted to acute left coronary artery ligation.
Basic Res Cardiol. 1990 Jul-Aug;85(4):404-10. doi: 10.1007/BF01907132.
4
Lidocaine has a narrow antiarrhythmic dose range against ventricular arrhythmias induced by programmed electrical stimulation in conscious postinfarction dogs.利多卡因在清醒的心肌梗死后犬中，针对程序性电刺激诱发的室性心律失常，其抗心律失常剂量范围较窄。
Naunyn Schmiedebergs Arch Pharmacol. 1992 Aug;346(2):213-8. doi: 10.1007/BF00165304.