Rasmussen F, Gustavson K H, Bille B
Clin Genet. 1984 Feb;25(2):148-54. doi: 10.1111/j.1399-0004.1984.tb00477.x.
Sixteen patients (13 males and 3 females) with minor neurodevelopmental disorders from 7 families were examined in an etiologic study. In four of the families (3, 5, 6 and 7) no brain damaging factors could be traced in the prenatal, perinatal or postnatal periods, and genetic main etiologies were strongly suspected. In one family (1) alcohol abuse during the pregnancies was thought to be an etiologically contributing factor. Potentially brain damaging factors were demonstrated in at least one patient from each of the remaining two families (2 and 4), and might, in these cases, have interacted with hereditary factors.
在一项病因学研究中,对来自7个家庭的16名患有轻度神经发育障碍的患者(13名男性和3名女性)进行了检查。在其中4个家庭(3、5、6和7)中,在产前、围产期或产后均未发现脑损伤因素,因此强烈怀疑存在遗传主要病因。在一个家庭(1)中,怀孕期间的酒精滥用被认为是一个病因相关因素。在其余两个家庭(2和4)的至少一名患者中发现了潜在的脑损伤因素,在这些病例中,这些因素可能与遗传因素相互作用。