Hill R P, Porter L S, Ives S A, Wong J T
Int J Radiat Oncol Biol Phys. 1984 Mar;10(3):369-73. doi: 10.1016/0360-3016(84)90056-7.
Initial studies were performed to examine the potential of perfused dextran-hemoglobin to protect pig skin or mouse bone marrow cells against radiation damage. Some protection was indicated in both systems. In the pig skin a protection factor of 1.5 was observed for moist desquamation, and 2.0 for necrosis. These results suggest the possibility of using blood substitutes to induce tissue hypoxia for therapeutic purposes.
