Ueda M, Kaneda T, Oka T, Torii S
J Oral Maxillofac Surg. 1984 Apr;42(4):213-23. doi: 10.1016/0278-2391(84)90452-x.
Mucosal defects in the oral cavities of 35 dogs were repaired with reversed dermal grafts, full-thickness skin grafts, and dermal grafts. Comparative observations were made for up to two years to analyze the healing processes. The reversed dermal grafts were covered by surrounding mucosal epithelium and formed normal mucosal tissue that maintained its characteristics for two years. Histologic and scanning electron microscopic examination revealed that the epithelial appendages underwent degeneration, presumably through being embedded by the grafting of the dermis inside out. Epithelialization of the dermal grafts occurred from both surrounding mucosal epithelium and ancillary skin appendages. The full-thickness skin grafts maintained their original structure and function over the two-year observation period. It appears from this investigation that the reversed dermal graft method has definite advantages over full-thickness skin grafting and dermal grafting.
用反转真皮移植物、全厚皮片和真皮移植物修复35只犬口腔黏膜缺损。进行长达两年的比较观察以分析愈合过程。反转真皮移植物被周围黏膜上皮覆盖，形成正常黏膜组织，且该组织特征维持了两年。组织学和扫描电子显微镜检查显示，上皮附属器发生退化，推测是由于真皮由内向外移植将其包埋所致。真皮移植物的上皮化来自周围黏膜上皮和附属皮肤附属器。在两年的观察期内，全厚皮片保持了其原始结构和功能。从本次研究看来，反转真皮移植法相较于全厚皮片移植和真皮移植具有明显优势。
