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[超强脉冲超短紫外线对增殖期和静止期海拉细胞DNA复制及转录功能作用的比较]

[Comparison of the action of powerful pulses of ultrashort UV on the DNA replication and transcription functions in proliferating and resting HeLa cells].

作者信息

Karu T I, Kalendo G S, Letokhov V S

出版信息

Radiobiologiia. 1984 Jan-Feb;24(1):17-20.

PMID:6200896
Abstract

It was established that the response of proliferating and resting HeLa cells to irradiation with single powerful UV-pulses (lambda = 266 nm, the pulse duration 3.10(-11) sec) is different. In the proliferating cells, the rate of DNA synthesis is markedly changed (accelerated or retarded) while the rate of RNA synthesis changes slightly. In the resting cells, RNA synthesis is stimulated while DNA synthesis remains at the control level. In all cases, the processes observed depend upon the intensity and the number of pulses.

摘要

已确定增殖期和静止期的海拉细胞对单次强紫外脉冲(波长λ = 266 nm,脉冲持续时间3×10⁻¹¹秒)照射的反应不同。在增殖期细胞中,DNA合成速率显著改变(加速或减慢),而RNA合成速率变化轻微。在静止期细胞中,RNA合成受到刺激,而DNA合成保持在对照水平。在所有情况下,观察到的这些过程取决于脉冲强度和脉冲数量。

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