Gerlach A, Eiche T
Radiologe. 1984 Mar;24(3):125-9.
100 patients with squamous cell carcinoma of the head and neck, who underwent a bleomycin therapy pre- and postoperative have been followed up retrospectively for radiological signs of bleomycin-typical side-effects of the lung. The frequency of such changes was 24% and there were 2 peaks after 1 week and 4-6 weeks from the start of therapy. An increased risk to develop an interstitial exsudation and fibrosis seems to exist only for patients with preexistent emphysema of the lung.
100例头颈部鳞状细胞癌患者在术前和术后接受了博来霉素治疗,对其肺部博来霉素典型副作用的放射学征象进行了回顾性随访。此类改变的发生率为24%,在治疗开始后1周和4 - 6周出现两个高峰。似乎只有肺部已有肺气肿的患者发生间质性渗出和纤维化的风险增加。