Martensson H G, Akande B, Yeo C, Jaffe B M
Surgery. 1984 May;95(5):567-71.
Experiments were performed to determine whether substance P plays a physiologic role as an enterogastrone. Basal substance P levels averaged 6.4 +/- 0.2 pg/ml in dogs prepared with gastric and duodenal fistulas. Infusion of substance P at 5 ng/kg/min increased circulating hormone concentrations by more than 1 pg/ml and inhibited pentagastrin-stimulated (4 micrograms/kg/hr) gastric acid secretion by 44% (from 10.9 +/- 1.8 to 6.1 +/- 1.6 mEq/30 min); a similar dose of substance P (7 ng/kg/min) did not alter gastrin levels from the basal level of 19.8 +/- 1.2 fmol/ml. Duodenal acidification (with 0.1N HCl at 5 ml/min for 10 minutes) similarly inhibited pentagastrin-stimulated gastric fistula output (from 8.2 +/- 0.9 to an average of 5.0 +/- 0.9 mEq/30 min for the 30 minutes after irrigation) but did not alter circulating substance P levels. Thus, although physiologic concentrations of substance P inhibit gastric fistula output, this peptide does not seem to be involved in the endogenous acid-mediated duodenal control of acid secretion.
进行实验以确定P物质是否作为肠抑胃素发挥生理作用。在制备了胃瘘和十二指肠瘘的犬中，基础P物质水平平均为6.4±0.2 pg/ml。以5 ng/kg/min的速度输注P物质可使循环激素浓度增加超过1 pg/ml，并抑制五肽胃泌素刺激（4微克/千克/小时）的胃酸分泌44%（从10.9±1.8降至6.1±1.6毫当量/30分钟）；相似剂量的P物质（7 ng/kg/min）并未使胃泌素水平从19.8±1.2 fmol/ml的基础水平改变。十二指肠酸化（以0.1N盐酸5 ml/min持续10分钟）同样抑制了五肽胃泌素刺激的胃瘘排出量（从8.2±0.9降至冲洗后30分钟内平均5.0±0.9毫当量/30分钟），但未改变循环中的P物质水平。因此，尽管生理浓度的P物质抑制胃瘘排出量，但该肽似乎并不参与内源性酸介导的十二指肠对胃酸分泌的控制。
