• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Reversal of guanethidine blockade of sympathetic nerve terminals by tetraethylammonium and 4-aminopyridine.四乙铵和4-氨基吡啶对胍乙啶所致交感神经末梢阻滞的逆转作用。
Br J Pharmacol. 1978 Jan;62(1):75-8. doi: 10.1111/j.1476-5381.1978.tb07008.x.
2
Effect of guanidine on release of noradrenaline from the perfused spleen of the cat.胍对猫灌注脾脏中去甲肾上腺素释放的影响。
Br J Pharmacol. 1979 Aug;66(4):537-46. doi: 10.1111/j.1476-5381.1979.tb13692.x.
3
Adrenergic nerve-blocking activity of a new guanidine derivative.一种新型胍衍生物的肾上腺素能神经阻滞活性
J Pharmacol Exp Ther. 1981 Dec;219(3):748-51.
4
Effect of tetraethylammonium on noradrenaline release from cat spleen treated with tetrodotoxin.四乙铵对用河豚毒素处理的猫脾脏去甲肾上腺素释放的影响。
Nature. 1978 Dec 7;276(5688):623-4. doi: 10.1038/276623a0.
5
Effect of tetraethylammonium and barium on the release of noradrenaline from the perfused cat spleen by nerve stimulation and potassium.四乙铵和钡对神经刺激及钾离子引起的灌注猫脾脏去甲肾上腺素释放的影响
Naunyn Schmiedebergs Arch Pharmacol. 1976 Jul;294(1):23-9. doi: 10.1007/BF00692781.
6
Interaction of phenoxybenzamine with guanethidine and bretylium at the sympathetic nerve endings of the isolated perfused spleen of the cat.苯氧苄胺与胍乙啶及溴苄铵在猫离体灌注脾脏交感神经末梢处的相互作用。
J Pharmacol Exp Ther. 1966 Feb;151(2):189-95.
7
Reversal of bretylium blockade of adrenergic nerve terminals by tetraethylammonium.四乙铵对溴苄铵所致肾上腺素能神经末梢阻滞的逆转作用。
Biochem Pharmacol. 1978 May 15;27(10):1512-3. doi: 10.1016/0006-2952(78)90111-9.
8
Effect of 4-aminopyridine on release of noradrenaline from the perfused cat spleen by nerve stimulation.4-氨基吡啶对神经刺激引起的灌注猫脾脏去甲肾上腺素释放的影响。
J Physiol. 1977 Nov;272(3):517-28. doi: 10.1113/jphysiol.1977.sp012057.
9
Ion dependence of the release of noradrenaline by tetraethylammonium and 4-aminopyridine from cat splenic slices.四乙铵和4-氨基吡啶从猫脾脏切片释放去甲肾上腺素的离子依赖性
Br J Pharmacol. 1985 Feb;84(2):299-308. doi: 10.1111/j.1476-5381.1985.tb12914.x.
10
Mechanism of the antagonism between guanethidine and dexamphetamine.胍乙啶与右旋苯丙胺之间的拮抗作用机制。
Br J Pharmacol. 1969 Mar;35(3):563-72. doi: 10.1111/j.1476-5381.1969.tb08297.x.

引用本文的文献

1
Inhibition by adrenergic neurone blocking agents of the relaxation induced by BRL 38227 in vascular, intestinal and uterine smooth muscle.肾上腺素能神经元阻断剂对BRL 38227诱导的血管、肠道和子宫平滑肌舒张的抑制作用。
Br J Pharmacol. 1992 Oct;107(2):288-95. doi: 10.1111/j.1476-5381.1992.tb12740.x.
2
Tracheal relaxation induced by potassium channel opening drugs: its antagonism by adrenergic neurone blocking agents.钾通道开放药物诱导的气管舒张：肾上腺素能神经元阻断剂对其的拮抗作用。
Br J Pharmacol. 1992 Aug;106(4):813-8. doi: 10.1111/j.1476-5381.1992.tb14417.x.
3
Effect of guanidine on release of noradrenaline from the perfused spleen of the cat.胍对猫灌注脾脏中去甲肾上腺素释放的影响。
Br J Pharmacol. 1979 Aug;66(4):537-46. doi: 10.1111/j.1476-5381.1979.tb13692.x.

本文引用的文献

1
A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.一项关于影响用于儿茶酚胺分析的氧化铝 - 三羟基吲哚法的因素的研究。
J Pharmacol Exp Ther. 1962 Dec;138:360-75.
2
Potentiation by tetraethylammonium of the response of the cat spleen to postganglionic sympathetic nerve stimulation.四乙铵对猫脾脏对节后交感神经刺激反应的增强作用。
J Pharmacol Exp Ther. 1967 Sep;157(3):532-40.
3
Release of noradrenaline by splenic nerve stimulation and its dependence on calcium.脾脏神经刺激引起去甲肾上腺素释放及其对钙的依赖性。
J Physiol. 1967 Jan;188(2):219-34. doi: 10.1113/jphysiol.1967.sp008135.
4
Interaction of phenoxybenzamine with guanethidine and bretylium at the sympathetic nerve endings of the isolated perfused spleen of the cat.苯氧苄胺与胍乙啶及溴苄铵在猫离体灌注脾脏交感神经末梢处的相互作用。
J Pharmacol Exp Ther. 1966 Feb;151(2):189-95.
5
Effect of cocaine, phenoxybenzamine and calcium on the inhibition of norepinephrine output from the cat spleen by guanthidine.可卡因、酚苄明和钙对胍乙啶抑制猫脾脏去甲肾上腺素释放的影响。
J Pharmacol Exp Ther. 1969 Feb;165(2):166-75.
6
[Antidromic activity induced by acetylcholine in the cardiac sympathetic nerve, and noradrenaline liberation under the influence of guanethidine].[乙酰胆碱在心脏交感神经中诱导的逆向活动以及胍乙啶影响下的去甲肾上腺素释放]
Helv Physiol Pharmacol Acta. 1968;26(3):CR352-4.
7
Modification of the evoked release of noradrenaline from the perfused cat spleen by various ions and agents.不同离子和试剂对灌注猫脾脏中去甲肾上腺素诱发释放的影响。
J Physiol. 1972 Mar;221(3):601-15. doi: 10.1113/jphysiol.1972.sp009770.
8
Spontaneous and evoked activity of motor nerve endings in calcium Ringer.在含钙任氏液中运动神经末梢的自发活动和诱发活动。
J Physiol. 1969 Aug;203(3):689-706. doi: 10.1113/jphysiol.1969.sp008887.
9
On the mechanism of the adrenergic nerve blocking action of bretylium.关于溴苄铵的肾上腺素能神经阻滞作用机制。
Naunyn Schmiedebergs Arch Pharmakol. 1969;265(3):260-77. doi: 10.1007/BF01002340.
10
Effect of tetraethylammonium and barium on the release of noradrenaline from the perfused cat spleen by nerve stimulation and potassium.四乙铵和钡对神经刺激及钾离子引起的灌注猫脾脏去甲肾上腺素释放的影响
Naunyn Schmiedebergs Arch Pharmacol. 1976 Jul;294(1):23-9. doi: 10.1007/BF00692781.

四乙铵和4-氨基吡啶对胍乙啶所致交感神经末梢阻滞的逆转作用。

Reversal of guanethidine blockade of sympathetic nerve terminals by tetraethylammonium and 4-aminopyridine.

作者信息

Kirpekar M, Kirpekar S M, Prat J C

出版信息

Br J Pharmacol. 1978 Jan;62(1):75-8. doi: 10.1111/j.1476-5381.1978.tb07008.x.

DOI:10.1111/j.1476-5381.1978.tb07008.x
PMID:620099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1667782/
Abstract

1 The effect of tetraethylammonium (TEA) and 4-aminopyridine (4-AP) on the inhibitory effect of guanethidine on noradrenaline (NA) release was investigated in the perfused spleen of the cat. 2 Guanethidine blocked the release of NA evoked by nerve stimulation. TEA and 4-AP readily reversed this inhibitory effect, and the NA output was nearly doubled after repeated stimulation of the nerves. On subsequent perfusion with Krebs solution without TEA or 4-AP, the inhibitory effect of guanethidine reappeared. 3 The reversal of guanethidine blockade of sympathetic nerves by TEA and 4-AP is discussed.

摘要

1 研究了四乙铵（TEA）和4-氨基吡啶（4-AP）对胍乙啶抑制猫灌流脾脏中去甲肾上腺素（NA）释放作用的影响。2 胍乙啶可阻断神经刺激诱发的NA释放。TEA和4-AP能轻易逆转这种抑制作用，在反复刺激神经后，NA释放量几乎增加了一倍。随后用不含TEA或4-AP的 Krebs 溶液灌流时，胍乙啶的抑制作用又重新出现。3 讨论了TEA和4-AP对胍乙啶阻断交感神经作用的逆转。