四乙铵和4-氨基吡啶对胍乙啶所致交感神经末梢阻滞的逆转作用。
Reversal of guanethidine blockade of sympathetic nerve terminals by tetraethylammonium and 4-aminopyridine.
作者信息
Kirpekar M, Kirpekar S M, Prat J C
出版信息
Br J Pharmacol. 1978 Jan;62(1):75-8. doi: 10.1111/j.1476-5381.1978.tb07008.x.
Abstract
1 The effect of tetraethylammonium (TEA) and 4-aminopyridine (4-AP) on the inhibitory effect of guanethidine on noradrenaline (NA) release was investigated in the perfused spleen of the cat. 2 Guanethidine blocked the release of NA evoked by nerve stimulation. TEA and 4-AP readily reversed this inhibitory effect, and the NA output was nearly doubled after repeated stimulation of the nerves. On subsequent perfusion with Krebs solution without TEA or 4-AP, the inhibitory effect of guanethidine reappeared. 3 The reversal of guanethidine blockade of sympathetic nerves by TEA and 4-AP is discussed.
摘要
1 研究了四乙铵（TEA）和4-氨基吡啶（4-AP）对胍乙啶抑制猫灌流脾脏中去甲肾上腺素（NA）释放作用的影响。2 胍乙啶可阻断神经刺激诱发的NA释放。TEA和4-AP能轻易逆转这种抑制作用，在反复刺激神经后，NA释放量几乎增加了一倍。随后用不含TEA或4-AP的 Krebs 溶液灌流时，胍乙啶的抑制作用又重新出现。3 讨论了TEA和4-AP对胍乙啶阻断交感神经作用的逆转。
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本文引用的文献
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A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.一项关于影响用于儿茶酚胺分析的氧化铝 - 三羟基吲哚法的因素的研究。
J Pharmacol Exp Ther. 1962 Dec;138:360-75.
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Potentiation by tetraethylammonium of the response of the cat spleen to postganglionic sympathetic nerve stimulation.四乙铵对猫脾脏对节后交感神经刺激反应的增强作用。
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Release of noradrenaline by splenic nerve stimulation and its dependence on calcium.脾脏神经刺激引起去甲肾上腺素释放及其对钙的依赖性。
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J Pharmacol Exp Ther. 1966 Feb;151(2):189-95.
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J Pharmacol Exp Ther. 1969 Feb;165(2):166-75.
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Helv Physiol Pharmacol Acta. 1968;26(3):CR352-4.
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