Andersson K E, Bende M
Ann Otol Rhinol Laryngol. 1984 Mar-Apr;93(2 Pt 1):179-82. doi: 10.1177/000348948409300216.
The blood flow in the human nasal mucosa is controlled by the functional state of the resistance vessels. This blood flow was studied by means of the 133Xe washout method. Using topical application of drugs that stimulate or block adrenoceptors, including clinical doses of nasal decongestants, we classified the adrenoceptors of the resistance vessels in the mucosa. The results suggest that stimulation of alpha2-adrenoceptors causes a reduction of nasal mucosal blood flow; stimulation of alpha1- and beta2-adrenoceptors seems to have no significant effects. Drugs that selectively stimulate alpha2-adrenoceptors, as well as those with preference for alpha1-adrenoceptors, cause nasal decongestion. To avoid the negative effects of a nasal mucosal blood flow reduction, it is suggested that a nasal decongestant with an alpha1-adrenoceptor stimulating effect should be preferable to a drug acting mainly on alpha2-adrenoceptors, provided that the decongestive effects are equal.
人类鼻黏膜中的血流受阻力血管功能状态的控制。采用¹³³Xe洗脱法对该血流进行了研究。通过局部应用刺激或阻断肾上腺素能受体的药物，包括临床剂量的鼻减充血剂，我们对黏膜中阻力血管的肾上腺素能受体进行了分类。结果表明，刺激α₂ - 肾上腺素能受体会导致鼻黏膜血流减少；刺激α₁ - 和β₂ - 肾上腺素能受体似乎没有显著影响。选择性刺激α₂ - 肾上腺素能受体的药物以及优先作用于α₁ - 肾上腺素能受体的药物会引起鼻充血减轻。为避免鼻黏膜血流减少的负面影响，建议在减充血效果相同的情况下，具有α₁ - 肾上腺素能受体刺激作用的鼻减充血剂比主要作用于α₂ - 肾上腺素能受体的药物更可取。
