正常免疫反应过程中自身抗独特型抗体的产生。IX. 自身抗独特型抗体的特性及其产生

Production of auto-anti-idiotypic antibody during the normal immune response. IX. Characteristics of the auto-anti-idiotype antibody and its production.

作者信息

Goidl E A, Samarut C, Schneider-Gadicke A, Hochwald N L, Thorbecke G J, Siskind G W

出版信息

Cell Immunol. 1984 Apr 15;85(1):25-33. doi: 10.1016/0008-8749(84)90274-0.

PMID:6201287

Abstract

Using hapten-reversible inhibition of plaque formation as an assay for auto-anti-idiotype antibody (anti-Id) and as a means for following idiotype (Id) expression, we have obtained evidence that following immunization with trinitrophenyl (TNP) conjugates (a) there are differences in Id expression in the anti-TNP antibody response to different TNP conjugates although there is some overlap; (b) different strains, although showing some differences in Id expression, tend to produce cross-reactive Ids, thus no obvious allotype linked inheritance of Id expression is observed in this heterogeneous immune response; (c) the auto-anti-Id produced following immunization with TNP-Brucella abortus or TNP-Ficoll tends to be of the IgG2a and IgG2b isotypes.

摘要

利用半抗原对噬菌斑形成的可逆抑制作用作为自身抗独特型抗体（抗Id）的检测方法以及追踪独特型（Id）表达的手段，我们已获得如下证据：在用三硝基苯基（TNP）偶联物免疫后，（a）尽管存在一些重叠，但针对不同TNP偶联物的抗TNP抗体应答中Id表达存在差异；（b）不同品系虽然在Id表达上存在一些差异，但倾向于产生交叉反应性Id，因此在这种异质性免疫应答中未观察到明显的与同种异型相关的Id表达遗传现象；（c）用TNP - 流产布鲁氏菌或TNP - 聚蔗糖免疫后产生的自身抗Id往往属于IgG2a和IgG2b同种型。