Sellers T D, DiMarco J P
Chest. 1984 May;85(5):647-9. doi: 10.1378/chest.85.5.647.
New pharmacologic agents have been developed which are highly effective in suppressing ventricular premature beats, but their chronic efficacy in patients with sustained ventricular arrhythmias remains uncertain. We observed the appearance of ventricular tachycardia with an unusual sinusoidal QRS complex in three of five such patients treated with flecainide acetate, 200 mg twice daily. Our experience suggests that the early reports of successful suppression of ventricular premature beats in stable patients may not be directly applicable to sicker patients with recurrent sustained ventricular arrhythmias. In these patients, life-threatening arrhythmias may appear as the first manifestation of drug toxicity.
已经研发出了新型药物制剂，它们在抑制室性早搏方面非常有效，但对于持续性室性心律失常患者，其长期疗效仍不确定。我们观察到，在五例接受每日两次200毫克醋酸氟卡尼治疗的此类患者中，有三例出现了伴有异常正弦QRS波群的室性心动过速。我们的经验表明，早期关于成功抑制稳定患者室性早搏的报道可能并不直接适用于患有复发性持续性室性心律失常的病情较重的患者。在这些患者中，危及生命的心律失常可能会作为药物毒性的首发表现出现。
