Krensky A M, Robbins E, Springer T A, Burakoff S J
J Immunol. 1984 May;132(5):2180-2.
Three cell surface antigens associated with the CTL-target cell interaction were previously identified by generation of mAb against OKT4+, HLA-DR-specific CTL, and selection for inhibition of cytolysis in a 51Cr-release assay. In this report, we showed that these mAb inhibit cytolysis by blocking CTL-target cell conjugate formation. It appears that LFA-1, LFA-2, and LFA-3 are cell surface structures involved in strengthening effector-target adhesion that accompanies antigen-specific recognition.
先前通过针对OKT4 +、HLA - DR特异性CTL产生单克隆抗体，并在51Cr释放试验中选择抑制细胞溶解，鉴定出三种与CTL - 靶细胞相互作用相关的细胞表面抗原。在本报告中，我们表明这些单克隆抗体通过阻断CTL - 靶细胞共轭物的形成来抑制细胞溶解。看来LFA - 1、LFA - 2和LFA - 3是参与增强伴随抗原特异性识别的效应器 - 靶标粘附的细胞表面结构。
