Ito Y, Tsurudome M, Yamada A, Hishiyama M
J Immunol. 1984 May;132(5):2440-4.
Twenty-two species of lectin were tested for their ability to induce interferon (IFN) in mouse spleen cells. Twenty-two species of lectins representing four groups, based on competition patterns with monosaccharides, were examined for their ability to induce IFN in cultured mouse spleen cells. The lectins, all belonging to the third group (concanavalin A, succinylated concanavalin A, Lens culinaris lectins type A and B, and poke weed mitogen) induced IFN mainly composed of IFN gamma. They were either T cell or T/B cell mitogens. Five nonmitogenic lectins, Lotus tetragonolobus seed lectin, crude and type II lectins of Ulex europeus, Bandeiraea simplicifolia type II and Salanum tuberosame lectins, and wheat germ agglutinin belonging to either the first or the third group, induced IFN beta. The production of IFN during stimulation IFN beta- and IFN gamma-inducing lectins followed different kinetic curves. WGA induced IFN in circulation when injected i.p. in mice, and a peak titer was found 2 hr after inoculation.
对22种凝集素诱导小鼠脾细胞产生干扰素（IFN）的能力进行了测试。基于与单糖的竞争模式，将22种凝集素分为四组，检测了它们在培养的小鼠脾细胞中诱导IFN的能力。所有属于第三组的凝集素（刀豆球蛋白A、琥珀酰化刀豆球蛋白A、扁豆凝集素A和B以及商陆丝裂原）诱导产生的IFN主要由IFNγ组成。它们要么是T细胞有丝分裂原，要么是T/B细胞有丝分裂原。五种无丝分裂原凝集素，即百脉根种子凝集素、荆豆粗凝集素和II型凝集素、双花扁豆II型凝集素、马铃薯凝集素以及属于第一组或第三组的麦胚凝集素，诱导产生IFNβ。在刺激过程中，IFNβ诱导凝集素和IFNγ诱导凝集素诱导产生IFN的动力学曲线不同。腹腔注射WGA可在小鼠体内循环中诱导产生IFN，接种后2小时发现滴度峰值。
