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1
The role of cyclic nucleotides and calcium in the mediation of the modulatory effects of octopamine on locust skeletal muscle.环核苷酸和钙在章鱼胺对蝗虫骨骼肌调节作用介导中的作用。
J Physiol. 1984 Mar;348:325-40. doi: 10.1113/jphysiol.1984.sp015113.
2
A modulatory octopaminergic neurone increases cyclic nucleotide levels in locust skeletal muscle.一个调节性章鱼胺能神经元可提高蝗虫骨骼肌中的环核苷酸水平。
J Physiol. 1984 Mar;348:307-24. doi: 10.1113/jphysiol.1984.sp015112.
3
Identified octopaminergic neurons modulate contractions of locust visceral muscle via adenosine 3',5'-monophosphate (cyclic AMP).已鉴定出的章鱼胺能神经元通过3',5'-单磷酸腺苷（环磷酸腺苷）调节蝗虫内脏肌肉的收缩。
Brain Res. 1986 Jan 22;363(2):340-9. doi: 10.1016/0006-8993(86)91020-6.
4
Studies on the mode of action of octopamine, 5-hydroxytryptamine and proctolin on a myogenic rhythm in the locust.章鱼胺、5-羟色胺和促肠肌肽对蝗虫肌源性节律作用方式的研究。
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J Neurophysiol. 1998 Aug;80(2):785-97. doi: 10.1152/jn.1998.80.2.785.

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Insect octopamine receptors: a new classification scheme based on studies of cloned Drosophila G-protein coupled receptors.昆虫章鱼胺受体：基于对克隆的果蝇G蛋白偶联受体研究的新分类方案。
Invert Neurosci. 2005 Nov;5(3-4):111-8. doi: 10.1007/s10158-005-0001-z. Epub 2005 Oct 24.
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A modulatory octopaminergic neurone increases cyclic nucleotide levels in locust skeletal muscle.一个调节性章鱼胺能神经元可提高蝗虫骨骼肌中的环核苷酸水平。
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6
Regional differences in responsiveness to octopamine within a locust skeletal muscle.蝗虫骨骼肌内对章鱼胺反应性的区域差异。
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9
A concentration-dependent localization of octopamine-sensitive adenylate cyclase activity in locust skeletal muscle.章鱼胺敏感腺苷酸环化酶活性在蝗虫骨骼肌中的浓度依赖性定位。
Histochemistry. 1989;92(3):255-60. doi: 10.1007/BF00500926.

本文引用的文献

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PERIPHERAL INHIBITION IN SKELETAL MUSCLE OF INSECTS.昆虫骨骼肌中的外周抑制
J Neurophysiol. 1965 May;28:497-518. doi: 10.1152/jn.1965.28.3.497.
2
THE EFFECT OF CALCIUM IONS ON POTASSIUM CONTRACTURE IN A LOCUST LEG MUSCLE.钙离子对蝗虫腿部肌肉钾挛缩的影响。
J Physiol. 1965 Mar;177(1):94-102. doi: 10.1113/jphysiol.1965.sp007577.
3
The effects of adrenaline, noradrenaline and isoprenaline on skeletal muscle contractions in the cat.肾上腺素、去甲肾上腺素和异丙肾上腺素对猫骨骼肌收缩的影响。
J Physiol. 1958 Nov 10;144(1):92-107. doi: 10.1113/jphysiol.1958.sp006088.
4
Octopamine mediated relaxation of maintained and catch tension in locust skeletal muscle.章鱼胺介导蝗虫骨骼肌持续张力和牵张张力的松弛。
J Physiol. 1982 Mar;324:93-112. doi: 10.1113/jphysiol.1982.sp014102.
5
Fine structure of an octopaminergic neuron and its terminals.章鱼胺能神经元及其终末的精细结构。
J Neurobiol. 1980;11(1):103-26. doi: 10.1002/neu.480110109.
6
Forskolin: a unique diterpene activator of cyclic AMP-generating systems.福司可林：一种独特的环磷酸腺苷生成系统二萜激活剂。
J Cyclic Nucleotide Res. 1981;7(4):201-24.
7
Multiple receptor types for octopamine in the locust.蝗虫体内章鱼胺的多种受体类型。
J Physiol. 1981 Sep;318:99-122. doi: 10.1113/jphysiol.1981.sp013853.
8
Effects of catecholamines and cyclic amp on excitation--contraction coupling in isolated skeletal muscle fibres of the frog.儿茶酚胺和环磷酸腺苷对青蛙离体骨骼肌纤维兴奋-收缩偶联的影响。
J Physiol. 1981 Jun;315:267-82. doi: 10.1113/jphysiol.1981.sp013747.
9
Calcium and cyclic AMP-dependent regulation of myofibrillar calmodulin-dependent myosin light chain kinases from cardiac and skeletal muscles.钙和环磷酸腺苷对心肌和骨骼肌肌原纤维钙调蛋白依赖性肌球蛋白轻链激酶的调节作用
Adv Cyclic Nucleotide Res. 1981;14:375-90.
10
Adenosine receptors and the regulation of adenylate cyclase.腺苷受体与腺苷酸环化酶的调节
Adv Cyclic Nucleotide Res. 1981;14:199-214.

环核苷酸和钙在章鱼胺对蝗虫骨骼肌调节作用介导中的作用。

The role of cyclic nucleotides and calcium in the mediation of the modulatory effects of octopamine on locust skeletal muscle.

作者信息

Evans P D

出版信息

J Physiol. 1984 Mar;348:325-40. doi: 10.1113/jphysiol.1984.sp015113.

DOI:10.1113/jphysiol.1984.sp015113
PMID:6201610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1199405/
Abstract

The role of cyclic AMP and calcium in the mediation of the effects of octopamine has been investigated in the extensor tibiae muscle of the hind leg of the locust. Elevation of cyclic AMP levels in the preparation by means of the phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (IBMX), by means of the diterpene adenylate cyclase activator, forskolin, and by means of cyclic nucleotide analogues mimics the post-synaptic effects of octopamine application at different frequencies of neuronal stimulation. These conditions also mimic the presynaptic effects of octopamine on spontaneous release of transmitter from the slow motoneurone. The effects of octopamine on the preparation are calcium sensitive, with the maximal sensitivity occurring between 0.5 and 4.0 mM-external calcium. The results are discussed in terms of the role of cyclic AMP and calcium in the mediation of the effects of octopamine.

摘要

环磷酸腺苷（cAMP）和钙在介导章鱼胺作用中的角色，已在蝗虫后腿胫节伸肌中进行了研究。通过磷酸二酯酶抑制剂3-异丁基-1-甲基黄嘌呤（IBMX）、二萜腺苷酸环化酶激活剂福斯可林以及环核苷酸类似物，提高标本中的cAMP水平，可模拟在不同神经元刺激频率下施加章鱼胺的突触后效应。这些条件还模拟了章鱼胺对慢运动神经元递质自发释放的突触前效应。章鱼胺对标本的作用对钙敏感，最大敏感性出现在细胞外钙浓度为0.5至4.0 mM之间。本文根据cAMP和钙在介导章鱼胺作用中的角色对结果进行了讨论。