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章鱼胺、5-羟色胺和促肠肌肽对蝗虫肌源性节律作用方式的研究。

Studies on the mode of action of octopamine, 5-hydroxytryptamine and proctolin on a myogenic rhythm in the locust.

作者信息

Evans P D

出版信息

J Exp Biol. 1984 May;110:231-51. doi: 10.1242/jeb.110.1.231.

DOI:10.1242/jeb.110.1.231
PMID:6205115
Abstract

The modes of action of the modulatory compounds octopamine, 5-hydroxytryptamine (5-HT) and proctolin on the frequency of the myogenic rhythm of the extensor-tibiae muscle of the hindleg of the locust, Schistocerca americana gregaria, have been investigated. 5-HT and proctolin increase the frequency of the myogenic rhythm and the results of the present study suggest that they may mediate their effects by increasing the levels of cyclic AMP in the pacemaker of the myogenic bundle. In contrast, octopamine reduces the frequency of the myogenic rhythm and appears to mediate its effects by a mechanism that does not involve an elevation of cyclic AMP. A number of other possible mechanisms for the action of octopamine are discussed.

摘要

已对调节性化合物章鱼胺、5-羟色胺（5-HT）和促肠肌肽对美洲沙漠蝗后腿胫节伸肌肌源性节律频率的作用方式进行了研究。5-HT和促肠肌肽可提高肌源性节律的频率，本研究结果表明它们可能通过提高肌源性束起搏器中环状AMP的水平来介导其作用。相比之下，章鱼胺可降低肌源性节律的频率，并且似乎通过一种不涉及环状AMP升高的机制来介导其作用。文中还讨论了章鱼胺作用的其他一些可能机制。

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1
Studies on the mode of action of octopamine, 5-hydroxytryptamine and proctolin on a myogenic rhythm in the locust.章鱼胺、5-羟色胺和促肠肌肽对蝗虫肌源性节律作用方式的研究。
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