Laurian N, Sadov R, Strauss M, Kessler E
Laryngoscope. 1984 May;94(5 Pt 1):684-7.
A rare case of an 81/2 year old boy with a stage III well differentiated squamous cell carcinoma of the larynx, which responded to chemotherapy and irradiation, is reported. It is the 56th case in children up to 15 years of age and 20th case in children 10 years old or younger reported since 1868. Carcinoma of the larynx in children has similar clinicopathological features to those of adult laryngeal carcinoma, but markedly differs as concerning sex incidence ratio. The main differential diagnosis is juvenile papillomatosis and the principal risk factor is previous cervical irradiation. Delayed diagnosis is frequent since clinical manifestations might be attributed to the normal laryngeal maturation process or to a common respiratory infection. Treatment is problematic, for special effort must be made to preserve laryngeal anatomy and function and to avoid complications. Prognosis of childhood laryngeal cancer is unclear since the reported survival rates are not tumor stage related.
报告了一例罕见的8岁半男孩，患有III期高分化喉鳞状细胞癌，对化疗和放疗有反应。这是自1868年以来报告的15岁以下儿童中的第56例病例，也是10岁及以下儿童中的第20例病例。儿童喉癌具有与成人喉癌相似的临床病理特征，但在性别发病率方面明显不同。主要鉴别诊断是青少年乳头状瘤病，主要危险因素是既往颈部放疗。由于临床表现可能归因于正常的喉部成熟过程或常见的呼吸道感染，延迟诊断很常见。治疗存在问题，因为必须特别努力保留喉部解剖结构和功能并避免并发症。儿童喉癌的预后尚不清楚，因为报告的生存率与肿瘤分期无关。
