Tesch P A, Kaiser P, Kaijser L
Acta Physiol Scand. 1984 Jan;120(1):71-5. doi: 10.1111/j.1748-1716.1984.tb07375.x.
Isometric muscle endurance was measured in fourteen physically active men without (placebo) and after acute oral administration of 160 mg propranolol (Inderal). Quadriceps muscle contractions were sustained at 65% maximum voluntary contraction (MVC) to exhaustion. Muscle biopsies were obtained from m. vastus lateralis at rest for subsequent histochemical analysis for myofibrillar ATPase and amylase-PAS in order to determine fiber type composition and capillary density. The time to exhaustion was shorter (p less than 0.01) during beta-blockade (0.82 +/- 0.22) min than placebo (0.90 +/- 0.23) min. Changes in endurance time, induced by beta-blockade, were not correlated with any of the muscle morphological or histochemical variables examined. It is concluded that muscular performance is impaired as a result of beta-blockade on muscle tissue irrespective of any concomitant change in central circulation.
对14名身体活跃的男性进行了等长肌肉耐力测试，一组为未服用药物（安慰剂）状态，另一组在急性口服160毫克普萘洛尔（心得安）后进行测试。股四头肌收缩维持在最大自主收缩（MVC）的65%直至力竭。在静息状态下从股外侧肌获取肌肉活检样本，随后进行肌原纤维ATP酶和淀粉酶-过碘酸希夫反应（PAS）的组织化学分析，以确定纤维类型组成和毛细血管密度。在β受体阻滞剂作用期间，力竭时间（0.82±0.22分钟）比服用安慰剂时（0.90±0.23分钟）更短（p<0.01）。β受体阻滞剂引起的耐力时间变化与所检测的任何肌肉形态学或组织化学变量均无相关性。得出的结论是，β受体阻滞剂对肌肉组织的作用会损害肌肉性能，而与中心循环的任何伴随变化无关。
