甲状腺素优先刺激发育中大鼠大脑皮层分离出的神经细胞核的转录。
Thyroxine preferentially stimulates transcription by isolated neuronal nuclei in the developing rat brain cortex.
作者信息
Lindholm D B
出版信息
FEBS Lett. 1984 Jun 11;171(2):240-4. doi: 10.1016/0014-5793(84)80495-0.
PMID:6202558
Abstract
The administration of thyroxine to neonatal rats stimulates RNA synthesis by neuronal nuclei isolated from the developing rat brain cortex. Glial nuclei are relatively resistant to thyroxine treatment. The activity of neuronal RNA polymerase II is particularly stimulated by the hormone. Thyroxine also affects neuronal chromatin structure as shown by changes in the relative proportion of different subnuclear fractions obtained by gentle micrococcal nuclease digestion of nuclei from hormone-treated rats.
摘要
给新生大鼠注射甲状腺素可刺激从发育中的大鼠大脑皮层分离出的神经元细胞核的RNA合成。神经胶质细胞核对甲状腺素治疗相对不敏感。甲状腺素特别能刺激神经元RNA聚合酶II的活性。甲状腺素还会影响神经元染色质结构，这可通过对经激素处理的大鼠细胞核进行温和的微球菌核酸酶消化后获得的不同亚核组分相对比例的变化来表明。
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