Rosatelli C, Falchi A M, Scalas M T, Tuveri T, Cao A
Hemoglobin. 1984;8(1):17-24. doi: 10.3109/03630268408996957.
This study shows a minor, statistically non significant increase, of beta-chain synthesis from 18 to 24 weeks gestation in both normal and beta o-thalassemia heterozygous fetuses with no significant changes in the ratio between the values for the two groups as a function of gestational age. This result indicates that at midtrimester pregnancy the developmental pattern of Hb F to Hb A switching in beta o-thalassemia heterozygotes is similar to that of normal fetuses.
本研究表明，在正常胎儿和β⁰地中海贫血杂合子胎儿中，从妊娠18周到24周，β链合成有轻微增加，统计学上无显著意义，两组数值之比随孕周变化无显著变化。这一结果表明，在妊娠中期，β⁰地中海贫血杂合子中Hb F向Hb A转换的发育模式与正常胎儿相似。
