P物质部分介导八肽胆囊收缩素（CCK - 8）对豚鼠回肠而非胆囊的作用的进一步证据：使用P物质拮抗剂的研究。
Further evidence that substance P partly mediates the action of cholecystokinin octapeptide (CCK-8) on the guinea pig ileum but not gall bladder: studies with a substance P antagonist.
作者信息
Chang R S, Lotti V J, Chen T B
出版信息
Neurosci Lett. 1984 Apr 20;46(1):71-5. doi: 10.1016/0304-3940(84)90201-5.
The substance P antagonist, [D-Pro4-D- Trp7 ,9,10]substance P4-11, caused a pig parallel shift to the right of the cholecystokinin (CCK-8) dose-response curve in guinea pig ileum longitudinal muscle without changing the maximal contraction. The shift of the CCK-8 dose response was markedly reduced after desensitization of the tissues to substance P (SP). The SP antagonist had no effect upon CCK-8 responses of the guinea pig gall bladder, [125I]CCK pancreatic binding or contractions of the guinea pig ileum produced by acetylcholine or electrical stimulation. The data provide additional evidence for the involvement of SP in the action of CCK-8 on the guinea pig ileum but not the gall bladder.
P物质拮抗剂[D-脯氨酸4-D-色氨酸7,9,10]P物质4-11使豚鼠回肠纵肌中胆囊收缩素（CCK-8）剂量反应曲线平行右移，而不改变最大收缩力。组织对P物质（SP）脱敏后，CCK-8剂量反应的右移明显减小。SP拮抗剂对豚鼠胆囊的CCK-8反应、[125I]CCK胰腺结合或乙酰胆碱或电刺激引起的豚鼠回肠收缩均无影响。这些数据为SP参与CCK-8对豚鼠回肠而非胆囊的作用提供了额外证据。
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