P物质拮抗剂可抑制豚鼠支气管平滑肌的神经介导非胆碱能收缩。
Neuronally mediated non-cholinergic contraction of guinea-pig bronchial smooth muscle is inhibited by a substance P antagonist.
作者信息
Leander S, Grundström N, Andersson R G, Håkanson R
出版信息
Agents Actions. 1984 Apr;14(3-4):315-8. doi: 10.1007/BF01973819.
PMID:6203347
Abstract
The isolated main bronchi of the guinea-pig respond to electrical field stimulation with a twitch followed by a slow contraction. Atropine blocked the slow contraction. The substance P antagonist, (D-Pro2, D- Trp7 ,9)-SP, greatly reduced the atropine-resistant contraction. The results suggest the involvement of substance P in non-cholinergic neurotransmission in the guinea-pig airways.
摘要
豚鼠分离出的主支气管对电场刺激产生先抽搐后缓慢收缩的反应。阿托品可阻断缓慢收缩。P物质拮抗剂（D-脯氨酸2，D-色氨酸7，9）-P可显著降低阿托品抵抗性收缩。结果表明P物质参与豚鼠气道的非胆碱能神经传递。
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