Devine P, Ucci A A, Krain H, Gavris V E, Bhagavan B S, Heaney J A, Alroy J
Am J Clin Pathol. 1984 Jun;81(6):728-32. doi: 10.1093/ajcp/81.6.728.
Nephrogenic adenoma a rare bladder, ureter, or urethral lesion, is of disputed pathogenesis, metaplastic and congenital etiologies both being implicated in its development. Since light and electron microscopy have been unable to fully resolve the lesion's pathogenesis, the authors used biotinylated lectins as probes and avidin-biotin peroxidase complex (ABC) as a visualant to study cases of nephrogenic adenomas and compared their lectin binding patterns with those of normal transitional epithelium, human embryonic kidneys, and cases of cystitis cystica and glandularis and squamous metaplasia of the bladder in an effort to clarify this issue. Only the epithelial lining of the luminal surface and tubuli in nephrogenic adenoma and tubules in embryonic kidney exhibited free PNA receptor sites. The striking staining similarities between the epithelial components of nephrogenic adenomas and mesonephric and metanephric tubules complement previous findings concerning the origin of nephrogenic adenoma.
肾源性腺瘤是一种罕见的膀胱、输尿管或尿道病变，其发病机制存在争议，化生和先天性病因都被认为与它的发生有关。由于光镜和电镜无法完全阐明该病变的发病机制，作者使用生物素化凝集素作为探针，抗生物素蛋白-生物素过氧化物酶复合物（ABC）作为可视化剂来研究肾源性腺瘤病例，并将它们的凝集素结合模式与正常移行上皮、人胚胎肾以及膀胱囊性膀胱炎、腺性膀胱炎和鳞状化生病例的模式进行比较，以努力阐明这个问题。只有肾源性腺瘤管腔表面的上皮衬里和小管以及胚胎肾中的小管显示出游离的PNA受体位点。肾源性腺瘤的上皮成分与中肾和后肾小管之间显著的染色相似性补充了先前关于肾源性腺瘤起源的研究结果。
