Sackett G P
Am J Ment Defic. 1984 Mar;88(5):469-76.
Delayed development and permanent retardation can result from genetic, prenatal, perinatal, and postnatal factors often acting through complex interactions. For human subjects experimental study of such developmental systems is often impossible due to confounding of variables and ethical considerations. One alternative is to study an animal model. A nonhuman primate model for studying genetic, physiological, and psychosocial processes producing delayed development was described in this paper. The model focuses on parental risk for poor reproductive outcomes using pigtailed monkey (Macaca nemestrina) subjects. In initial experiments subjects were offspring from high- and low-risk breeders who were nursery-reared with no postnatal contact with their parents. Results showed that both maternal and paternal factors are associated with delayed development in systems ranging from tooth eruption to concept learning ability.
发育延迟和永久性智力迟钝可能由遗传、产前、围产期和产后因素导致，这些因素常常通过复杂的相互作用发挥作用。对于人类受试者而言，由于变量混淆和伦理考量，对这类发育系统进行实验研究往往是不可能的。一种替代方法是研究动物模型。本文描述了一种用于研究导致发育延迟的遗传、生理和心理社会过程的非人类灵长类动物模型。该模型聚焦于使用猪尾猴（食蟹猴）受试者时，父母出现不良生殖结果的风险。在最初的实验中，受试者是来自高风险和低风险繁殖者的后代，它们在育婴室饲养，出生后与父母没有接触。结果表明，从牙齿萌出到概念学习能力等系统中，母系和父系因素都与发育延迟有关。
