Hirase T, Araki S
Brain Dev. 1984;6(1):10-6. doi: 10.1016/s0387-7604(84)80003-0.
We analyzed and quantified the microcomponents of protein fractions in the cerebrospinal fluid of patients with various types of muscular dystrophy. The degenerative pattern is characterized by an increase in the prealbumin fraction and a decrease in the gamma-globulin fraction as shown in the Duchenne and congenital muscular dystrophy. The increase in CSF IgG, gamma-globulin fraction, and myelin basic protein is shown in the myotonic dystrophy. In addition to the lowness of IQ, and the abnormality of EEG and brain CT, abnormal CSF proteins obviously suggest the presence of CNS involvement in muscular dystrophy.
我们分析并量化了各类肌营养不良患者脑脊液中蛋白质组分的微量成分。如杜氏肌营养不良和先天性肌营养不良所示，其退变模式的特征为前清蛋白组分增加而γ-球蛋白组分减少。强直性肌营养不良则表现为脑脊液免疫球蛋白G、γ-球蛋白组分及髓鞘碱性蛋白增加。除了智商低、脑电图和脑部CT异常外，脑脊液蛋白质异常明显提示肌营养不良存在中枢神经系统受累情况。
