Shimada F
Gan To Kagaku Ryoho. 1984 Jun;11(6):1182-8.
In the period between November 1972 and December 1982, 27 patients with nasopharyngeal carcinoma were treated. The male to female ratio was 20:7. and ages ranged from 17 to 71 years with a median of 46. Most of the cases were classified as stage 4. Histological findings according to the WHO classification revealed undifferentiated carcinoma in two-thirds of all cases. The cumulative survival rate was 41.9% over a three-year-period and 17.1% over a five-year-period. Both primacy lesion and regional lymph node metastases were well controlled by radiation therapy. In patients with cranial nerve palsy and/or destruction of the skull base, distant metastasis developed severely later. Most of the distant metastases were found in bone and/or in the lung. In 14 of the 27 cases, systemic chemotherapy using various drugs, either alone or in combination, was performed. No complete response was obtained. Partial response was observed when adriamycin and vincristine were used in combination. Minor response was observed when pepleomycin or adriamycin was used alone. The sequential combination of bleomycin and mitomycin-c also produced minor response. Pre-radiation chemotherapy is recommended to obtain more effective results. The combined use of cis-diamminedichloroplatinum (cisplatin) and pepleomycin (peplomycin) was reported to be effective in nasopharyngeal carcinoma. The testing of pre-radiation chemotherapy using this combination is encouraged for in the treatment of nasopharyngeal carcinoma.
1972年11月至1982年12月期间，对27例鼻咽癌患者进行了治疗。男女比例为20:7，年龄在17岁至71岁之间，中位数为46岁。大多数病例被归类为IV期。根据世界卫生组织分类的组织学检查结果显示，所有病例中有三分之二为未分化癌。三年期累积生存率为41.9%，五年期为17.1%。原发灶和区域淋巴结转移均通过放射治疗得到良好控制。在有颅神经麻痹和/或颅底破坏的患者中，远处转移出现得较晚且严重。大多数远处转移发生在骨骼和/或肺部。27例患者中有14例单独或联合使用了各种药物进行全身化疗。未获得完全缓解。阿霉素和长春新碱联合使用时观察到部分缓解。单独使用平阳霉素或阿霉素时观察到轻微缓解。博来霉素和丝裂霉素-C序贯联合也产生了轻微缓解。建议进行放疗前化疗以获得更有效的结果。据报道，顺二氯二氨铂（顺铂）和平阳霉素联合使用对鼻咽癌有效。鼓励在鼻咽癌治疗中采用这种联合方案进行放疗前化疗试验。
