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[恶性肿瘤患者粒细胞吞噬作用、血清免疫球蛋白、急性期蛋白及补体C3的同步研究]

[Simultaneous studies of granulocyte phagocytosis, serum immunoglobulins, acute phase proteins and the 3d complement component in patients with malignant tumors].

作者信息

Friedrich A, Walther E, Bomski B, Glass W

出版信息

Arch Geschwulstforsch. 1984;54(2):137-52.

PMID:6203497
Abstract

In a clinical study granulocyte phagocytosis, serum levels of IgG and IgA and of the acute phase proteins ceruloplasmin, alpha-1-antitrypsin, transferrin, and of the 3rd component of complement (C3) are simultaneously determined in tumor patients and compared with healthy probands of the same age and with patients being under general surgical treatment. There was found a negative correlation between granulocyte phagocytosis and the IgG level and a positive correlation between phagocytosis and the C3 level in each group. Despite of some significant differences between all groups of probands with respect to the measured parameters no new essential information for clinical use could be received, thus the determination of granulocyte phagocytosis remains the only recommended method.

摘要

在一项临床研究中,同时测定肿瘤患者的粒细胞吞噬作用、血清IgG和IgA水平以及急性期蛋白铜蓝蛋白、α-1-抗胰蛋白酶、转铁蛋白和补体第三成分(C3)的水平,并与相同年龄的健康受试者以及接受普通外科治疗的患者进行比较。在每组中发现粒细胞吞噬作用与IgG水平之间呈负相关,吞噬作用与C3水平之间呈正相关。尽管所有受试者组在测量参数方面存在一些显著差异,但未获得可用于临床的新的重要信息,因此粒细胞吞噬作用的测定仍然是唯一推荐的方法。

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