前列腺素合成抑制剂对肿瘤生长和血管生成的影响。大鼠实验研究。
Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.
作者信息
Peterson H I
出版信息
Invasion Metastasis. 1983;3(3):151-9.
PMID:6203870
Abstract
The growth rate (studied by mean tumor dry weight) and vascularization (studied by microangiography) of two transplantable rat tumors, a 20-methylcholanthrene-induced fibrosarcoma and a hepatoma, were significantly reduced by three prostaglandin synthesis inhibitors, indomethacin, diclofenac-sodium and aspirin, irrespective of whether the drugs were administered early or late during tumor growth.
摘要
两种可移植大鼠肿瘤（一种是20-甲基胆蒽诱导的纤维肉瘤，另一种是肝癌）的生长速率（通过肿瘤平均干重研究）和血管生成（通过微血管造影研究），被三种前列腺素合成抑制剂（吲哚美辛、双氯芬酸钠和阿司匹林）显著降低，无论这些药物是在肿瘤生长早期还是晚期给药。
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