Bucht G, Adolfsson R, Winblad B
J Am Geriatr Soc. 1984 Jul;32(7):491-8. doi: 10.1111/j.1532-5415.1984.tb02233.x.
Patients who had Alzheimer's disease-senile dementia of the Alzheimer type (AD/SDAT) or multi-infarct dementia (MID) were compared with a group of controls. Demented patients had approximately the same degree of dementia and the same duration of illness. The MID group had a significantly higher mean age than the AD/SDAT group. Sixty-three per cent of the AD/SDAT patients were free of other diseases, while 65 per cent of the MID patients had cardiovascular disease. Thirty per cent of the MID patients had a history of previous depression, while only 5 per cent of the AD/SDAT patients had had depression. At the time of the investigation, however, AD/SDAT patients showed significantly more signs of depression than the MID patients. Focal neurologic signs were found in 70 per cent of the MID patients and only 6 per cent of the AD/SDAT patients. The electrocardiogram was normal for every AD/SDAT patient, while 75 per cent of the MID patients had abnormal ECGs. Electroencephalography showed generalized slow frequencies in 79 per cent of the AD/SDAT patients and localized slow frequencies and abnormalities in 65 per cent of the MID patients. Computed tomography of the brain showed that MID patients had significantly greater dilation of the ventricular system, while cortical atrophy did not differ significantly among the three groups. Homovanillic acid in the cerebrospinal fluid was significantly lower in the AD/SDAT group as compared with controls.
将患有阿尔茨海默病 - 阿尔茨海默型老年痴呆症（AD/SDAT）或多发性梗死性痴呆（MID）的患者与一组对照组进行比较。痴呆患者的痴呆程度大致相同，病程也相同。MID组的平均年龄显著高于AD/SDAT组。63%的AD/SDAT患者没有其他疾病，而65%的MID患者患有心血管疾病。30%的MID患者有既往抑郁症病史，而只有5%的AD/SDAT患者曾患抑郁症。然而，在调查时，AD/SDAT患者比MID患者表现出明显更多的抑郁迹象。70%的MID患者有局灶性神经体征，而AD/SDAT患者只有6%有此体征。每位AD/SDAT患者的心电图均正常，而75%的MID患者心电图异常。脑电图显示，79%的AD/SDAT患者有普遍性慢频率，65%的MID患者有局限性慢频率和异常。脑部计算机断层扫描显示，MID患者的脑室系统扩张明显更严重，而三组之间的皮质萎缩没有显著差异。与对照组相比，AD/SDAT组脑脊液中的高香草酸显著降低。
