Leake A, Chisholm G D, Habib F K
J Endocrinol. 1984 Jul;102(1):73-6. doi: 10.1677/joe.0.1020073.
The interaction between prolactin and zinc was examined in vitro in the human prostate gland. The results indicated that prolactin did not modulate the acute uptake of zinc into benign prostatic hypertrophy tissue whereas zinc, in contrast, increased the uptake of prolactin into the prostate gland. Our study further showed that the augmented uptake of prolactin by zinc was partly due to an increase in the non-specific binding properties of the peptide hormone. We were also able to demonstrate that the specific binding of 125I-labelled human prolactin to the receptor was reduced in the presence of zinc by a competitive mechanism.
在人体前列腺中对催乳素与锌之间的相互作用进行了体外研究。结果表明，催乳素并未调节锌向良性前列腺增生组织的急性摄取，而相比之下，锌却增加了催乳素向前列腺的摄取。我们的研究进一步表明，锌使催乳素摄取增加部分归因于该肽类激素非特异性结合特性的增强。我们还能够证明，在锌存在的情况下，通过竞争机制，125I标记的人催乳素与受体的特异性结合减少。
