Doyle A E
J Cardiovasc Pharmacol. 1984;6 Suppl 1:S115-20. doi: 10.1097/00005344-198400061-00020.
Rats with two-kidney, one-clip hypertension (2K1C) have a marked rise in plasma renin activity (PRA) and, when drinking 0.9% NaCl as their sole source of sodium, have increased exchangeable and total body sodium levels. These changes are reversed by the administration of captopril. The one-kidney, one-clip (1K1C) model has no rise in PRA or increase in body sodium level after either an early or a late contralateral nephrectomy. The data indicate that hypertension in the 2K1C model is due to the high angiotensin levels in these animals. Activation of the renin-angiotensin system requires the presence of the contralateral kidney but is not the result of sodium loss from that kidney. The reason for activation of the renin-angiotensin system in the 2K1C hypertensive rat remains obscure.
双肾单夹高血压（2K1C）大鼠的血浆肾素活性（PRA）显著升高，当饮用0.9%氯化钠作为唯一钠源时，其可交换钠和总体钠水平会升高。给予卡托普利可逆转这些变化。单肾单夹（1K1C）模型在早期或晚期对侧肾切除术后，PRA没有升高，身体钠水平也没有增加。数据表明，2K1C模型中的高血压是由于这些动物体内的高血管紧张素水平所致。肾素-血管紧张素系统的激活需要对侧肾脏的存在，但不是该肾脏钠丢失的结果。2K1C高血压大鼠肾素-血管紧张素系统激活的原因仍不清楚。
