Popova N K, Lobacheva I I, Karmanova I G, Shilling N V
Pharmacol Biochem Behav. 1984 May;20(5):653-7. doi: 10.1016/0091-3057(84)90179-5.
It has been established that brain serotonin (5-HT) is involved in the control of behavioral phenomena in amphibians. The transition of frogs from active wakefulness to sleep-like states was accompanied by alteration of brain 5-HT metabolism, i.e., in sleep-like state with plastic muscle tone 5-hydroxyindoleacetic acid (5-HIAA) level was reduced and in sleep-like state with rigid muscle tone both brain 5-HIAA and 5-HT were decreased. An experimental decrease of brain 5-HT level by inhibition of its biosynthesis by p-chlorophenylalanine (200 mg/kg) induced the sleep-like state of catatonic type, i.e., the state which was characterized by lowered brain 5-HT.
已经确定，脑血清素（5-羟色胺，5-HT）参与两栖动物行为现象的控制。青蛙从活跃觉醒状态转变为类睡眠状态时，伴随着脑5-HT代谢的改变，即，在具有可塑性肌张力的类睡眠状态下，5-羟吲哚乙酸（5-HIAA）水平降低，而在具有僵硬肌张力的类睡眠状态下，脑5-HIAA和5-HT均降低。通过对氯苯丙氨酸（200mg/kg）抑制其生物合成来实验性降低脑5-HT水平，会诱导出紧张型类睡眠状态，即其特征为脑5-HT降低的状态。
