Pharmacological properties of new cyclic derivatives of phenylsuccinimide and their influence on noradrenaline, dopamine, serotonin, 5-hydroxyindoleacetic acid, gamma-aminobutyric acid concentrations and monoaminooxidase activity in animal brains.

Three new cyclic derivatives of phenylsuccinimide (I-10, I-11 and IL-7) were subjected to preliminary pharmacological studies in animals. Minimal peripheral action and inhibitory influence on the CNS were noted (only IL-7) was found to stimulate CNS). Neurotoxic effects were similar to those of the classical succinimides . Anticonvulsant activity and behavioral effects of tested compounds are discussed in the light of their influence on neurotransmitters.