Induced muscular work overload and disuse on the serum carbohydrate metabolism of dog, Canis domesticus.

Serum carbohydrate metabolism was analysed in control, control stimulated, denervation atrophied and denervation stimulated dogs, Canis domesticus. The muscular training has resulted in the hypoglycemia through the mobilization of glucose into both hexose mono- and diphosphate pathways. The denervation atrophy, on the contrary, resulted in hyperglycemia because of exactly opposite changes in the carbohydrate metabolism in the serum and also possibly due to the lack of uptake by the muscle. The training programme of electrical stimulation applied to this denervated muscle has wiped off the hyperglycemia. The importance of muscular work in modulating the serum carbohydrate metabolism was indicated.