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用跨突触示踪剂（小麦胚芽凝集素-辣根过氧化物酶）和细胞色素氧化酶染色在猕猴中研究视网膜-膝状体-纹状体通路的皮质内终止。

Intracortical termination of the retino-geniculo-striate pathway studied with transsynaptic tracer (wheat germ agglutinin-horseradish peroxidase) and cytochrome oxidase staining in the macaque monkey.

作者信息

Itaya S K, Itaya P W, Van Hoesen G W

出版信息

Brain Res. 1984 Jun 25;304(2):303-10. doi: 10.1016/0006-8993(84)90334-2.

DOI:10.1016/0006-8993(84)90334-2
PMID:6204719
Abstract

The tracer, wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP), was used as a transneuronal marker in the macaque monkey to study retino-geniculo-striate pathway terminals in area 17. Concomitantly, we stained matching sections for metabolic capacity using the cytochrome oxidase staining technique. Terminal labeling by WGA-HRP and cytochrome oxidase activity staining revealed duplicate patterns in layers II and III, IVA, IVC alpha, IVC beta, and VI. The absence of WGA-HRP-labeled neuronal cell bodies in area 17 supports the conclusion that WGA-HRP is a transsynaptic marker in the macaque visual pathways.

摘要

将与辣根过氧化物酶结合的小麦胚芽凝集素（WGA-HRP）作为示踪剂，在猕猴中用作跨神经元标记物，以研究17区的视网膜-膝状体-纹状通路终末。同时，我们使用细胞色素氧化酶染色技术对匹配切片进行代谢能力染色。WGA-HRP的终末标记和细胞色素氧化酶活性染色在II和III层、IVA、IVCα、IVCβ和VI层显示出重复模式。17区缺乏WGA-HRP标记的神经元细胞体，支持了WGA-HRP是猕猴视觉通路中跨突触标记物的结论。

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