Lieber I H, Stoneburner S D, Floyd M, McGuffin W L
Cancer. 1984 Sep 1;54(5):808-10. doi: 10.1002/1097-0142(19840901)54:5<808::aid-cncr2820540507>3.0.co;2-y.
A patient with a potassium wasting nephropathy secondary to chemotherapy simulating Bartter's syndrome is described. A 64-year-old woman with diffuse histiocytic lymphoma developed persistent hypokalemia following a course of Cytoxan (cyclophosphamide), Adriamycin (doxorubicin), vincristine, and prednisone (CHOP)-Bleo. The diagnosis of a functional Bartter's syndrome was concluded following evaluation of serial plasma renins, aldosterone levels, and urinary electrolytes. Evidence is suggestive that a subpopulation of patients receiving chemotherapy may develop a functional Bartter's syndrome, and it is important to consider this diagnosis in patients who develop hypokalemia subsequent to chemotherapy introduction.
本文描述了一名因化疗继发钾耗竭性肾病而酷似巴特综合征的患者。一名64岁弥漫性组织细胞淋巴瘤女性患者在接受环磷酰胺、阿霉素、长春新碱和泼尼松（CHOP）-博来霉素化疗后出现持续性低钾血症。在对系列血浆肾素、醛固酮水平及尿电解质进行评估后，得出功能性巴特综合征的诊断。有证据提示，接受化疗的部分患者可能会发生功能性巴特综合征，对于化疗后出现低钾血症的患者，考虑这一诊断很重要。
