Roth J D, Lukowiak K, Berry R W
Comp Biochem Physiol A Comp Physiol. 1984;78(1):83-9. doi: 10.1016/0300-9629(84)90097-5.
Stimulation of the branchial or either connective nerve of the abdominal ganglion of Aplysia californica evokes simultaneous responses in cells R15, L8, L9, and L11 which are indistinguishable from those arising from spontaneous interneuron II (INT II) activity. Threshold for the INT II-like response in all cells is identical, suggesting that the response is mediated by INT II activity. The magnitude of the response in each cell increases with stimulus intensity and is subject to both temporal and spatial summation, implying the existence of multiple fibres in each nerve which converge on INT II. Repetitive stimulation evokes long-lasting inhibition in R15. The onset of this phenomenon is always accompanied by an INT II burst in the other follower cells. Long-lasting inhibition in R15 is not accompanied by prolonged INT II activity, suggesting an endogenous mechanism of inhibition. The phosphodiesterase inhibitor, IBMX, potentiates the response of R15 to nerve stimulation without affecting threshold for the response. This is consistent with inhibition by a mechanism endogenous to R15.
刺激加州海兔腹神经节的鳃神经或任一连接神经，会在细胞R15、L8、L9和L11中引发同步反应，这些反应与自发中间神经元II（INT II）活动产生的反应无法区分。所有细胞中类似INT II反应的阈值相同，这表明该反应是由INT II活动介导的。每个细胞中反应的幅度随刺激强度增加，且受到时间和空间总和的影响，这意味着每条神经中存在多条纤维汇聚于INT II。重复刺激会在R15中引发持久抑制。这种现象的开始总是伴随着其他跟随细胞中的INT II爆发。R15中的持久抑制并不伴随着INT II活动的延长，这表明存在一种内源性抑制机制。磷酸二酯酶抑制剂IBMX增强了R15对神经刺激的反应，而不影响反应阈值。这与R15内源性机制的抑制作用一致。
