胰岛激活蛋白百日咳毒素可抑制钙离子诱导的以及鸟嘌呤核苷酸依赖性的组胺和花生四烯酸从大鼠肥大细胞中的释放。
Islet-activating protein, pertussis toxin, inhibits Ca2+-induced and guanine nucleotide-dependent releases of histamine and arachidonic acid from rat mast cells.
作者信息
Nakamura T, Ui M
出版信息
FEBS Lett. 1984 Aug 6;173(2):414-8. doi: 10.1016/0014-5793(84)80816-9.
PMID:6204890
Abstract
Islet-activating protein (IAP) suppressed Ca2+-induced histamine release and phospholipase A2 activation in Gpp(NH)p-loaded mast cells. Since the guanine nucleotide-binding protein involved in adenylate cyclase inhibition is known to lose its function upon being ADP-ribosylated by IAP, the nucleotide-binding protein is likely to mediate Ca2+-linked biosignalling leading to histamine secretion.
摘要
胰岛激活蛋白（IAP）可抑制Ca2+诱导的Gpp(NH)p预负载肥大细胞中组胺的释放以及磷脂酶A2的激活。由于已知参与抑制腺苷酸环化酶的鸟嘌呤核苷酸结合蛋白在被IAP进行ADP-核糖基化后会丧失其功能，所以该核苷酸结合蛋白可能介导了导致组胺分泌的Ca2+相关生物信号传导。
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