冷凝集素Vo。一种IgMλ单克隆人抗体，可识别在新生儿红细胞上完全表达的唾液酸决定抗原。
Cold agglutinin Vo. An IgM lambda monoclonal human antibody recognizing a sialic acid determined antigen fully expressed on newborn erythrocytes.
作者信息
Roelcke D, Kreft H, Pfister A M
出版信息
Vox Sang. 1984;47(3):236-41. doi: 10.1111/j.1423-0410.1984.tb01591.x.
An IgM lambda cold agglutinin reacted preferentially with newborn (i cord) and i adult erythrocytes. The whole serum of patient Vo and the antibody isolated by warm elution reacted moderately with native and neuraminidase-treated red cells but strongly with papainized red cells. Papainization of erythrocytes enhanced markedly the susceptibility of the corresponding antigen not only to antibody binding but also to the action of neuraminidase, indicating that sialic acid is the immunodominant component of the cryptic antigen. The cold agglutinin Vo is the first example of a human monoclonal antibody recognizing a sialic acid-dependent, developmentally regulated antigen fully expressed on newborn erythrocytes.
一种IgM λ冷凝集素优先与新生儿（脐血）和成人i型红细胞发生反应。患者Vo的全血清以及通过温热洗脱分离出的抗体与天然红细胞和经神经氨酸酶处理的红细胞反应中等，但与经木瓜蛋白酶处理的红细胞反应强烈。红细胞经木瓜蛋白酶处理后，相应抗原不仅对抗体结合的敏感性显著增强，而且对神经氨酸酶的作用也更敏感，这表明唾液酸是隐蔽抗原的免疫显性成分。冷凝集素Vo是识别一种依赖唾液酸且在新生儿红细胞上完全表达的发育调控抗原的人单克隆抗体的首个实例。
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