Takagi T, Leszczynski D, Toda T, Kummerow F, Nishimori I
Acta Pathol Jpn. 1984 May;34(3):529-36. doi: 10.1111/j.1440-1827.1984.tb07581.x.
Thrombi with newly formed vessels in thirteen human umbilical arteries were studied. Red blood cells formed masses which were covered by fibrin within twelve hours after birth. By the second day, the intima including endothelial cells was denuded. In the junctional area between the thrombi and the original intima on the sixth day, red blood cells were surrounded by endothelial-like cells, which displayed junctional complexes and did not show any connection with intact endothelial cells. These cells also exhibited filaments with fusiform densities, suggesting a probable origin from vascular smooth muscle cells. Examination of older specimens indicated that these were precursor structures of functional capillaries found in mature thrombi.
对13条人脐动脉中带有新形成血管的血栓进行了研究。出生后12小时内，红细胞形成团块，被纤维蛋白覆盖。到第二天，包括内皮细胞在内的内膜被剥脱。在第六天，血栓与原始内膜的交界区域，红细胞被内皮样细胞包围，这些细胞显示出连接复合体，且与完整的内皮细胞没有任何连接。这些细胞还表现出具有梭形密度的细丝，提示可能起源于血管平滑肌细胞。对更陈旧标本的检查表明，这些是在成熟血栓中发现的功能性毛细血管的前体结构。
