Matsumoto H, Shibata K, Suga M, Ito M, Yachi A
No To Shinkei. 1984 Jun;36(6):583-7.
A 17 year old high school boy experienced fever and diarrhea, which subsided within 4 days by appropriate medications. Six days later, however, he developed unsteadiness and limb spasm. On the morning of admission, he was found to have drowsiness, dysarthria, gait disturbance and involuntary jerks. When he was brought to the hospital, he was lethargic but could follow simple verbal commands. Frequent involuntary movements manifested by facial grimacings, limb spasms and twitchings with dystonic features were seen. Decorticate posturing was readily elicited by painful stimuli. There was no meningeal irritation sign or gross sensory impairment. The deep tendon reflexes were symmetrically exaggerated with bilateral Babinski signs. Bilateral lateral rectus muscle weakness was found together with mild ptosis and upward gaze limitation. Nystagmus was not present and the funduscopic examination was normal. Immediately he was placed on anticonvulsants, steroid hormone, gamma-globulin and antibiotics as well. A brain CT scan and a CSF examination revealed no abnormality. Meanwhile he continued to show a progressive deterioration associated with fever and status epilepticus, and within 24 hours he lapsed into coma in decorticate posture. An EEG obtained at the 3rd hospital day was compatible with spindle coma. In spite of aggressive treatment he remained febrile and comatous. Therefore, vidarabine (adenine arabinoside) was initiated from the 3rd hospital day for 5 days. Then he began to groan and show frequent choreic movements. For the subsequent 2 weeks he made a slow recovery.(ABSTRACT TRUNCATED AT 250 WORDS)
一名17岁的高中男生出现发热和腹泻症状,经适当药物治疗后4天内症状消退。然而,6天后,他出现了步态不稳和肢体痉挛。入院当天上午,发现他嗜睡、构音障碍、步态紊乱和不自主抽搐。被送往医院时,他昏昏欲睡,但能听从简单的口头指令。可见频繁的不自主运动,表现为面部鬼脸、肢体痉挛和伴有张力障碍特征的抽搐。疼痛刺激很容易引出去皮层姿势。没有脑膜刺激征或明显的感觉障碍。深腱反射对称亢进,双侧巴氏征阳性。发现双侧外直肌无力,伴有轻度上睑下垂和向上凝视受限。没有眼球震颤,眼底检查正常。他立即接受了抗惊厥药、类固醇激素、γ-球蛋白和抗生素治疗。脑部CT扫描和脑脊液检查均未发现异常。与此同时,他继续表现出与发热和癫痫持续状态相关的进行性恶化,24小时内陷入去皮层姿势的昏迷。入院第3天进行的脑电图检查结果与纺锤体昏迷相符。尽管进行了积极治疗,他仍发热且昏迷。因此,从入院第3天开始使用阿糖腺苷治疗5天。然后他开始呻吟并出现频繁的舞蹈样动作。在随后的2周里,他逐渐康复。(摘要截取自250字)