Adrouny A, Seraydarian A, Levine A M, Hungerford G F, Carmel R
Cancer. 1984 Oct 1;54(7):1374-8. doi: 10.1002/1097-0142(19841001)54:7<1374::aid-cncr2820540724>3.0.co;2-r.
A patient with eosinophilic leukemia was noted to have spontaneous fluctuations in his eosinophil and total leukocyte counts over a 3-year period. The range of eosinophil counts observed was from 736/microliters to 401,400/microliters. Sharp fluctuations occurred whether chemotherapy was administered at the nadir or the peak of a cycle or was withheld. A shortening of the cycle length from 44 to 25 days, and a marked increase in amplitude of the cycle occurred in the terminal phase of his illness. Two additional observations merit mention. An abnormal alpha-2 globulin of 40,000 molecular weight was detected in his serum. In addition, cyclic fluctuations of serum transcobalamin I that accompanied his cyclic eosinophil counts were noted, and eosinophils were documented for the first time to be rich sources of this protein.
一名嗜酸性粒细胞白血病患者在3年期间其嗜酸性粒细胞和白细胞总数出现自发波动。观察到的嗜酸性粒细胞计数范围为每微升736个至401,400个。无论化疗是在一个周期的最低点还是高峰期进行，还是停止化疗，都会出现急剧波动。在疾病的终末期，周期长度从44天缩短至25天，且周期幅度显著增加。另外两个观察结果值得一提。在他的血清中检测到一种分子量为40,000的异常α-2球蛋白。此外，还注意到血清转钴胺素I的周期性波动与他的周期性嗜酸性粒细胞计数相伴，并且首次证明嗜酸性粒细胞是这种蛋白质的丰富来源。
