柔红霉素-花生四烯酸复合物作为一种潜在的新型抗肿瘤药物。
Daunomycin-arachidonic acid complex as a potential new antitumor agent.
作者信息
Sasaki T, Tsukada Y, Deutsch H F, Hirai H
出版信息
Cancer Chemother Pharmacol. 1984;13(2):75-7. doi: 10.1007/BF00257117.
PMID:6205782
Abstract
A daunomycin-arachidonic acid complex (DM-C20:4) administered IV had a marked antitumor effect on the intraperitoneal growth of the AFP-producing hepatoma cell line, AH66. However, the daunomycin-arachidic acid (DM-C20:0) saturated fatty acid complex showed only the same antitumor effect on the AH66 cells as free daunomycin. It was demonstrated that the DM-C20:4 preparation maintained its chemical properties for some time in both plasma and liver homogenate.
摘要
静脉注射柔红霉素-花生四烯酸复合物（DM-C20:4）对产生甲胎蛋白的肝癌细胞系AH66的腹腔内生长有显著抗肿瘤作用。然而，柔红霉素-花生酸（DM-C20:0）饱和脂肪酸复合物对AH66细胞的抗肿瘤作用仅与游离柔红霉素相同。结果表明，DM-C20:4制剂在血浆和肝匀浆中能在一段时间内保持其化学性质。
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