• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微管相关蛋白map2的鉴定及其在培养细胞中期染色体上的结合位点。

Identification of the microtubule-associated protein map2 and its binding sites on metaphase chromosomes from cultured cells.

作者信息

Wandosell F, Rodríguez-Campos A, Fernández Piqueras J, Avila J

出版信息

Chromosoma. 1984;90(1):68-71. doi: 10.1007/BF00352280.

DOI:10.1007/BF00352280
PMID:6205832
Abstract

The microtubule-associated protein MAP2, which binds preferentially to AT sequences of DNA, can bind to metaphase chromosomes. The binding pattern of MAP2 to chromosomes is similar to that found for the binding of the bisbenzimidazole derivative 33258 Hoechst, which also binds preferentially to AT-rich regions.

摘要

微管相关蛋白MAP2优先与DNA的AT序列结合，它能够与中期染色体结合。MAP2与染色体的结合模式，类似于双苯并咪唑衍生物Hoechst 33258的结合模式，后者也优先与富含AT的区域结合。

相似文献

1
Identification of the microtubule-associated protein map2 and its binding sites on metaphase chromosomes from cultured cells.微管相关蛋白map2的鉴定及其在培养细胞中期染色体上的结合位点。
Chromosoma. 1984;90(1):68-71. doi: 10.1007/BF00352280.
2
Controlled proteolysis of tubulin by subtilisin: localization of the site for MAP2 interaction.枯草杆菌蛋白酶对微管蛋白的可控蛋白水解作用：微管相关蛋白2（MAP2）相互作用位点的定位
Biochemistry. 1984 Sep 25;23(20):4675-81. doi: 10.1021/bi00315a024.
3
Binding of microtubule protein to DNA and chromatin: possibility of simultaneous linkage of microtubule to nucleic and assembly of the microtubule structure.微管蛋白与DNA和染色质的结合：微管与核酸同时连接及微管结构组装的可能性。
Nucleic Acids Res. 1981 Feb 25;9(4):895-908. doi: 10.1093/nar/9.4.895.
4
Binding of microtubule-associated proteins (MAPs) to rat brain mitochondria: a comparative study of the binding of MAP2, its microtubule-binding and projection domains, and tau proteins.微管相关蛋白（MAPs）与大鼠脑线粒体的结合：MAP2及其微管结合和突出结构域与tau蛋白结合的比较研究
Cell Motil Cytoskeleton. 1989;14(3):372-81. doi: 10.1002/cm.970140307.
5
Microtubule-associated protein, MAP2, is a calcium-binding protein.
Biochim Biophys Acta. 1988 May 12;965(2-3):195-201. doi: 10.1016/0304-4165(88)90056-6.
6
[Interaction of MAP2 protein of cytoplasmic microtubules with axoneme microtubules].
Dokl Akad Nauk SSSR. 1983;270(5):1249-53.
7
Phosphorylation determines the binding of microtubule-associated protein 2 (MAP2) to microtubules in living cells.磷酸化作用决定了微管相关蛋白2（MAP2）在活细胞中与微管的结合。
J Cell Biol. 1991 Aug;114(4):735-43. doi: 10.1083/jcb.114.4.735.
8
Interaction of brain cytoplasmic dynein and MAP2 with a common sequence at the C terminus of tubulin.脑胞质动力蛋白和微管相关蛋白2与微管蛋白C末端共同序列的相互作用。
Nature. 1989 Nov 30;342(6249):569-72. doi: 10.1038/342569a0.
9
[Binding of MAP1 protein to microtubules: the formation of "arms" and competition with MAP2 protein].[微管相关蛋白1（MAP1）与微管的结合：“臂”的形成及与微管相关蛋白2（MAP2）的竞争]
Dokl Akad Nauk SSSR. 1983;270(5):1243-6.
10
Stoichiometry of microtubule-associated protein (MAP2):tubulin and the localisation of the phosphorylation and cysteine residues along the MAP2 primary sequence.微管相关蛋白（MAP2）与微管蛋白的化学计量关系以及磷酸化和半胱氨酸残基沿MAP2一级序列的定位。
Eur J Biochem. 1984 Jun 15;141(3):599-608. doi: 10.1111/j.1432-1033.1984.tb08235.x.

引用本文的文献

1
High-Mr microtubule-associated proteins: properties and functions.高分子量微管相关蛋白：特性与功能
Biochem J. 1989 Apr 1;259(1):1-12. doi: 10.1042/bj2590001.
2
Relative position of constitutive heterochromatin and of nucleolar structures during mouse spermiogenesis.小鼠精子发生过程中组成型异染色质与核仁结构的相对位置。
Anat Embryol (Berl). 1987;175(4):467-75. doi: 10.1007/BF00309682.

本文引用的文献

1
Microtubule-associated protein MAP2 preferentially binds to a dA/dT sequence present in mouse satellite DNA.微管相关蛋白MAP2优先结合于小鼠卫星DNA中存在的dA/dT序列。
EMBO J. 1983;2(8):1229-34. doi: 10.1002/j.1460-2075.1983.tb01574.x.
2
Origin of kinetochore microtubules in Chinese hamster ovary cells.中国仓鼠卵巢细胞中动粒微管的起源
Chromosoma. 1980;81(3):483-505. doi: 10.1007/BF00368158.
3
Comparative measurement by radioimmunoassay of the brain microtubule-associated protein MAP2.采用放射免疫分析法对脑微管相关蛋白MAP2进行比较测量。
Mol Cell Biochem. 1981 Jul;37(3):185-9. doi: 10.1007/BF02354887.
4
Binding of microtubule protein to DNA and chromatin: possibility of simultaneous linkage of microtubule to nucleic and assembly of the microtubule structure.微管蛋白与DNA和染色质的结合：微管与核酸同时连接及微管结构组装的可能性。
Nucleic Acids Res. 1981 Feb 25;9(4):895-908. doi: 10.1093/nar/9.4.895.
5
Structure of the mammalian kinetochore.哺乳动物动粒的结构。
Chromosoma. 1981;82(2):153-70. doi: 10.1007/BF00286101.
6
Quantitation and characterization of the microtubule associated MAP2 in porcine tissues and its isolation from porcine (PK15) and human (HeLa) cell lines.猪组织中微管相关蛋白MAP2的定量与表征及其从猪（PK15）和人（HeLa）细胞系中的分离
Biochem Biophys Res Commun. 1982 Apr 29;105(4):1241-9. doi: 10.1016/0006-291x(82)90920-2.
7
Microtubule-associated proteins: a monoclonal antibody to MAP2 binds to differentiated neurons.微管相关蛋白：一种针对MAP2的单克隆抗体可与分化的神经元结合。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4741-5. doi: 10.1073/pnas.77.8.4741.
8
Different tubulin polymers are produced by microtubule-associated proteins MAP2 and tau in the presence of guanosine 5'-(alpha, beta-methylene)triphosphate.在鸟苷5'-（α，β-亚甲基）三磷酸存在的情况下，微管相关蛋白MAP2和tau会产生不同的微管蛋白聚合物。
J Biol Chem. 1980 Oct 10;255(19):8952-4.
9
Interspersion of mouse satellite deoxyribonucleic acid sequences.小鼠卫星脱氧核糖核酸序列的散布
Biochemistry. 1981 Jul 21;20(15):4393-8. doi: 10.1021/bi00518a025.
10
Use of an 125I-labelled DNA ligand to probe DNA structure.使用125I标记的DNA配体探测DNA结构。
Nature. 1983;302(5907):452-4. doi: 10.1038/302452a0.